Microbuckling of fibrin provides a mechanism for cell mechanosensing
CaltechAUTHORS
View Archive Info| Field | Value | |
| Title |
Microbuckling of fibrin provides a mechanism for cell mechanosensing
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| Creator |
Notbohm, Jacob
Lesman, Ayelet Rosakis, Phoebus Tirrell, David A. Ravichandran, Guruswami |
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| Description |
Biological cells sense and respond to mechanical forces, but how such a mechanosensing process takes place in a nonlinear inhomogeneous fibrous matrix remains unknown. We show that cells in a fibrous matrix induce deformation fields that propagate over a longer range than predicted by linear elasticity. Synthetic, linear elastic hydrogels used in many mechanotransduction studies fail to capture this effect. We develop a nonlinear microstructural finite-element model for a fibre network to simulate localized deformations induced by cells. The model captures measured cell-induced matrix displacements from experiments and identifies an important mechanism for long-range cell mechanosensing: loss of compression stiffness owing to microbuckling of individual fibres. We show evidence that cells sense each other through the formation of localized intercellular bands of tensile deformations caused by this mechanism.
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| Publisher |
The Royal Society
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| Date |
2015-07
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| Type |
Article
PeerReviewed |
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| Format |
application/pdf
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| Identifier |
http://authors.library.caltech.edu/59771/2/rsif20150320supp1.pdf
Notbohm, Jacob and Lesman, Ayelet and Rosakis, Phoebus and Tirrell, David A. and Ravichandran, Guruswami (2015) Microbuckling of fibrin provides a mechanism for cell mechanosensing. Journal of the Royal Society Interface, 12 (108). Art. No. 20150320. ISSN 1742-5689. http://resolver.caltech.edu/CaltechAUTHORS:20150819-141650427 <http://resolver.caltech.edu/CaltechAUTHORS:20150819-141650427> |
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| Relation |
http://resolver.caltech.edu/CaltechAUTHORS:20150819-141650427
http://authors.library.caltech.edu/59771/ |
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