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Microbuckling of fibrin provides a mechanism for cell mechanosensing

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Title Microbuckling of fibrin provides a mechanism for cell mechanosensing
 
Creator Notbohm, Jacob
Lesman, Ayelet
Rosakis, Phoebus
Tirrell, David A.
Ravichandran, Guruswami
 
Description Biological cells sense and respond to mechanical forces, but how such a mechanosensing process takes place in a nonlinear inhomogeneous fibrous matrix remains unknown. We show that cells in a fibrous matrix induce deformation fields that propagate over a longer range than predicted by linear elasticity. Synthetic, linear elastic hydrogels used in many mechanotransduction studies fail to capture this effect. We develop a nonlinear microstructural finite-element model for a fibre network to simulate localized deformations induced by cells. The model captures measured cell-induced matrix displacements from experiments and identifies an important mechanism for long-range cell mechanosensing: loss of compression stiffness owing to microbuckling of individual fibres. We show evidence that cells sense each other through the formation of localized intercellular bands of tensile deformations caused by this mechanism.
 
Publisher The Royal Society
 
Date 2015-07
 
Type Article
PeerReviewed
 
Format application/pdf
 
Identifier http://authors.library.caltech.edu/59771/2/rsif20150320supp1.pdf
Notbohm, Jacob and Lesman, Ayelet and Rosakis, Phoebus and Tirrell, David A. and Ravichandran, Guruswami (2015) Microbuckling of fibrin provides a mechanism for cell mechanosensing. Journal of the Royal Society Interface, 12 (108). Art. No. 20150320. ISSN 1742-5689. http://resolver.caltech.edu/CaltechAUTHORS:20150819-141650427 <http://resolver.caltech.edu/CaltechAUTHORS:20150819-141650427>
 
Relation http://resolver.caltech.edu/CaltechAUTHORS:20150819-141650427
http://authors.library.caltech.edu/59771/